Gardaí are warning motorists to avoid the main Tralee to Castlemaine road.
It's after a two-car collision on the N70 at Ballygamboon, about 3km from Castlemaine on the Tralee side.
Gardaí, the fire brigade and ambulance service are present at the scene.
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It's not believed the road will be closed for a long time, but there will be significant delays and motorists should use alternative routes.
Gardaí say there's no further information available at this time.