Kerry Fire Service is at the scene of a blaze near Moll's Gap.
The gorse fire broke out close to Five Mile Bridge on the N71 Killarney-Kenmare road.
Killarney gardaí say emergency services are at the scene.
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The road from Muckross to Moll's Gap is closed and likely to remain so for some time.
Anyone travelling to Kenmare should use the Kilgarvan road.