The Killarney Brewing & Distilling Company is to close with the loss of more than 50 jobs.
This means the business will cease operations at its premises including the brewery, whiskey distillery and visitors' centre in Fossa.
Its premises on the Muckross Road is also affected.
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Plans to merge with a US strategic partner fell through earlier this year and the company went into examinership.
One of the challenges faced by Killarney Brewing & Distillery Company has been the threat of and uncertainty over tariffs being imposed by the US.
The examiner appointed to the company is making an application to the High Court this morning.
