New Look is shutting its Irish operations, including its Killarney store, which had been in the process of recruiting staff.
The approximately one dozen people, who worked at the clothing chain in the Deerpark Retail Park, have lost their jobs.
Management arrived to the shop in Killarney at around midday, when the public was asked to leave, and staff were told of the nationwide liquidation.
The High Court today approved the appointment of liquidators to oversee the winding down of the business and its assets.
New Look says this decision was not taken lightly, but came after several years of sustained losses and challenging market conditions.
It employs 347 staff across 26 stores in 16 counties, its believed they will be subject to a redundancy programme.
The company says employees were notified immediately and more engagement will take place in the coming days.
A clearance sale will take place at New Look shops around the country on Sunday.
Irish customers will still be able to access New Look collections through retailers like ASOS and Very.