Southampton scored a couple of late goals to beat newly promoted Wrexham 2-1 and make it a winning return to the Championship.
They struck in the 90th and 96th minute to deny their opponents victory in their first second tier game in 43 years.
Isaac Price got the winner for West Brom - who started the Championship season with a 1-nil win against Blackburn.
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Middlesbrough were 1-nil winners at home to Swansea, while Stoke scored twice in stoppage time to beat Derby 3-1.
Portsmouth won 1-nil at Oxford and Charlton scored a late winner to get past Watford 1-nil.
Millwall won 2-1 at Norwich, QPR and Preston drew 1-all and it was goalless between Coventry and Hull.
