Connacht and Munster are both looking to secure Champions Cup rugby for next season.
Connacht will know exactly what they need, although a win is a must, by the time they kick-off away to Glasgow.
Munster also need a win over the Cell C Sharks in Durban, but a losing bonus point could be enough.
Leinster are guaranteed top spot regardless of their result away to the Vodacom Bulls.
Ulster have secured second place in the URC table.
Jacob Stockdale, John Cooney and Nick Timoney all crossed the whitewash in a 28-14 win at home to Edinburgh.
DHL Stormers registered a 38-points to 22 bonus point victory over Benetton.