Tottenham's hopes of a top four finish are all but over.
They were beaten 3-1 by Leeds in the first game of the day.
The result leaves Ryan Mason's side sixth and six points from the last Champions League place.
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Leeds meanwhile are ninth and look on course to finish in the top half of the table.
Crystal Palace lead already relegated Sheffield United 2-0 approaching full-time at Bramall Lane.
And the late game is Liverpool and Southampton at Anfield from 8-o'clock.