Manchester United will look to make it four wins from four under interim manager Michael Carrick this lunchtime.
United welcome Tottenham Hotspur to Old Trafford - though the hosts haven't beaten Spurs in their last four meetings.
Arsenal can move nine-points clear of second-place Manchester City, if they beat Sunderland at the Emirates.
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Third-place Aston Villa go to Bournemouth, Fulham take on Everton, Burnley face West Ham and Chelsea go to Wolves.
The evening late kick sees Keith Andrews' Brentford make the trip to Newcastle.
Last night Leeds took another big step toward safety with a 3-1 win against Nottingham Forest, which moved them nine-points clear of the relegation zone.
