Women's third seed Jessica Pegula has suffered a shock defeat in the last 16 at the French Open.
The American lost to French world number 361 Lois Boisson in three sets.
Earlier, Coco Gauff and Mirra Andreeva both advanced to the quarter-finals.
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In the men's singles, Novak Djokovic is safely through to the quarter-finals.
The 24-time Grand Slam champion beat Cameron Norrie in straight sets to book his place in the last eight.
World number three Alexander Zverev is through to the last eight after Tallon Griekspoor of the Netherlands retired due to injury during their fourth round clash.
