Wimbledon finalist Jasmine Paolini is the latest big name to suffer a US Open fourth round exit.
The seventh seed was beaten in straight sets by Karolina Muchova.
The Czech will face either Caroline Wozniacki or Beatriz Haddad-Maia in the quarter-finals.
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Later tonight, number-1 seed Iga Swiatek plays sixteenth seed Liudmila Samsanova.
Men’s top seed Jannik Sinner plays Tommy Paul.
And fifth seed Daniil Medvedev takes on Nuno Borges.
