Non-league Chesterfield were denied an FA Cup upset against second-tier West Brom.
A late equaliser saw a thrilling third-round tie end 3-all.
Among the other shocks, Blackpool thrashed top flight Nottingham Forest 4-1, Burnley were 4-2 winners over Premier League Bournemouth, and Fleetwood knocked QPR out 2-1.
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Boreham Wood - the lowest ranked team left - earnt a replay with a 1-all draw against Accrington.
Sheffield Wednesday will be hoping to upset high flying Newcastle among the evening kick-offs, before holders Liverpool host Wolves.
