Munster head coach Clayton McMillan has warned his players to expect a backlash from Leinster at Thomond Park tonight.
The Reds have a chance to complete a double over their rivals for the first time in a decade, having already between the reigning URC champions at Croke Park in October.
Captain Tadhg Beirne comes in to start for Munster, who come into the game in third place.
Prop Andrew Porter returns from injury for Leinster, with Harry Byrne selected to start at out-half.
Kick off in Thomond Park is at 19:45
Ulster and Connacht will both be looking to get back to winning ways in their inter-pro derby at Dexcom Stadium.
Connacht have lost their last nine interprovincial games, including their three most recent meetings with Ulster.
That one starts in Galway at 5:30
Elsewhere there is an Italian Derby when Zebre entertain Benetton at 2:30.
30 minutes later at 3, Glasgow Warriors make the short trip to face Edinburgh
