Munster flanker Jack O’Donoghue is facing three-to-four months out of action.
The province say he doesn’t require surgery on a knee injury, but will have the issue managed by their medical department.
Oli Jager continues to observe the return-to-play protocols, and his involvement in Saturday’s Investec Champions Cup clash with Northampton will be assessed closer to the game.
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Rob Herring’s Six Nations involvement is in jeopardy.
Ulster say the hooker will see a specialist this week having sustained a ‘significant’ elbow injury in training last week.
Meanwhile, Sean Reffell and Dave Ewers are both ruled out of Ulster’s Investec Champions Cup game away to Harlequins.
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Munster lock Evan O’Connell has been named captain of the Ireland under-20s ahead of their Six Nations campaign.
Head coach Richie Murphy has been able to retain five members of last year’s Grand Slam-winning squad.
