The Manchester derby headlines this afternoon's action in the Premier League.
Pep Guardiola's City have endured a poor start to the campaign, having lost two of their first three matches.
Matheus Cunha, Diogo Dalot and Mason Mount will all miss the game for United with Omar Marmoush out for City.
Reigning champions Liverpool look to maintain their 100 percent start when they go to Burnley.
There's a south coast derby in the Championship this lunchtime between Southampton and Portsmouth.
While reigning champions Celtic go to Kilmarnock in the Scottish Premiership.