Michael Carrick takes charge of his first Premier League game as Manchester United head coach this lunchtime.
They welcome cross-town rivals Manchester City for a derby at Old Trafford, with kickoff at half 12.
The Gunners are away to Nottingham Forest in the evening fixture at half 5.
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At 3 o'clock, Keith Andrews takes his Brentford side to Chelsea.
Tottenham boss Thomas Frank is under pressure ahead of the visit of West Ham to North London.
Liverpool can go 10 games unbeaten, if they avoid defeat at home to strugglers Burnley.
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Leeds welcome Fulham to Elland Road, and Sunderland host Crystal Palace.
