Leinster’s Will Connors will miss the rest of the season.
The flanker sustained a knee injury in last month’s defeat to Cardiff.
Connors had only returned to action following eight months out in November.
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Leinster duo James Lowe and Jimmy O’Brien have joined the Ireland squad ahead of Sunday’s Six Nations meeting with Italy.
Lowe had missed the first two games with a hamstring injury.
While O’Brien could win his first cap against the Azzurri.
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Wales have called-up Taulupe Faletau ahead of Saturday's Six Nations clash with England at Twickenham.
The Bath forward replaces Exeter's Christ Tshiunza, who's been released back to his club after picking up a hamstring injury.