It's a key night ahead in the race for Europe and the battle to beat the drop in the SSE Airtricity League Premier Division.
Waterford are in the relegation playoff position heading into their match at fifth placed Saint Pat's.
Drogheda are just behind the Saints on goal difference going into a game at fourth from bottom Galway United.
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In the first legs of the First Division playoffs, UCD host Bray and Richie Holland will be in charge of Cobh for their trip to Treaty United.
