Ireland captain Caelan Doris has been ruled out of Saturday's trip to Wales in rugby's Six Nations.
The Leinster back-row has been struggling with a knee injury which he picked up in the win against Scotland, and he's likely to be replaced by Jack Conan in Cardiff.
Hooker Ronan Kelleher and prop Tadhg Furlong are also out for this weekend but the coaching team are hopeful the forwards trio will be back to face France next month.
Assistant coach Andrew Goodman says they've good candidates to replace Doris against Wales, and also to fill in as captain
Meanwhile, the IRFU have confirmed today that Ireland will take on New Zealand, Australia and South Africa in their Autumn Nations Series fixtures this November.
Nine years on from their first-ever win over the All Blacks, the Men in Green return to Soldier Field in Chicago to take on Scott Robertson's side on November 1st.
The following Saturday, they take on Japan at the Aviva Stadium, before the visit of the Wallabies the following week.
They round off their Autumn window with the Springboks coming to Dublin on November 22nd.
England head coach Steve Borthwick's made one change to his starting line-up for Saturday's clash with Scotland.
Ollie Chessum comes in at lock for the Calcutta Cup match - with George Martin dropping out after suffering a knee injury against France in the last fixture.
Martin is among the replacements after returning to training earlier this week.
