Current leaders Arsenal welcome Brighton to the Emirates in one of five games that kick off at 3.
The Gunners are unbeaten at home in the league this season and have dropped just two points on home soil.
Diogo Jota's sons will be among the mascots ahead of Liverpool's match against Wolves at Anfield.
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Everton go to Burnley, West Ham face Fulham in a London derby and Keith Andrews' Brentford take on Bournemouth.
Aston Villa look to make it 11 straight wins in all competitions when they go to Chelsea in the evening game.
