Evan Ferguson will miss the Republic of Ireland's upcoming World Cup qualifiers against Portugal and Hungary.
A scan has confirmed that the striker suffered ankle ligament damage in Roma's win against Parma on Wednesday night.
Roma boss Gian Piero Gasperini had been hopeful it was just a sprain, but Ferguson is now likely to be out for three weeks.
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Ireland manager Heimir Hallgrimsson will name his squad next week, with Robbie Brady, Will Smallbone, Jason Knight, and Sammie Szmodics already out through injury.
