Kilkenny's Gavin Holohan scored two penalties as League Two Grimsby Town shocked Premier League Southampton 2-1.
Grimsby will face a trip to Brighton in the last eight.
Sheffield United upset Tottenham by 1 goal to nil to earn a quarter final tie with Blackburn Rovers.
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Burnley's reward for a 1-nil defeat of Fleetwood is a meeting with Manchester City.
