Liverpool or Tottenham will face Atletico Madrid, who beat Club Brugge 7-4 on aggregate.
There was a shock at San Siro, where last year's finalists Inter were knocked out by Norwegian outfit Bodo/Glimt after a 2-1 win on the night secured a 5-2 victory on aggregate.
Bayer Leverkusen also progressed - they played out a nil-all draw with Olympiacos to complete a 2-nil aggregate win.
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This evening, Real Madrid resume from 1-0 up in their tie against Benfica at the Bernabeu.
Benfica winger Gianluca Prestianni is provisionally suspended for tonight's game, as UEFA continue their investigation into alleged racist abuse toward Vinicius Junior during last week's first leg.
Kick-off is at 8.
Elsewhere, holders Paris Saint-Germain hold a 3-2 lead ahead of Monaco coming to the Parc des Princes.
And Juventus will bid to overturn a 5-2 deficit when they host Galatasaray in Turin.
The early game sees Borussia Dortmund take a 2-0 lead into their trip to Atalanta from quarter-to-6.
