Ireland head coach Andy Farrell has made nine changes to the team for Saturday's Nations Championship test against Japan.
Ciarán Frawley replaces Sam Prendergast at out-half, while there's an international debut from the start for Seán Jansen.
Billy Bohan, Sam Illo and Bryn Ward could also earn their first caps off the bench in Newcastle.
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Ireland (v Japan):
15. Jamie Osborne (Naas/Leinster)(16)
14. Jimmy O’Brien (Naas/Leinster)(12)
13. Robbie Henshaw (Buccaneers/Leinster)(84)
12. Stuart McCloskey (Bangor/Ulster)(29)
11. Jacob Stockdale (Lurgan/Ulster)(42)
10. Ciaran Frawley (UCD/Leinster)(13)
9. Craig Casey (Shannon/Munster)(28)
1. Tom O’Toole (Ballynahinch/Ulster)(22)
2. Rónan Kelleher (Lansdowne/Leinster)(49)
3. Thomas Clarkson (Blackrock College/Leinster)(14)
4. Tadhg Beirne (Lansdowne/Munster)(71)(captain)
5. James Ryan (UCD/Leinster)(81)
6. Jack Conan (Old Belvedere/Leinster)(60)
7. Nick Timoney (Queen’s University/Ulster)(12)
8. Sean Jansen (Connacht)*
Replacements:
16. Tom Stewart (Ballynahinch/Ulster)(5)
17. Billy Bohan (Corinthians/Connacht)*
18. Sam Illo (Buccaneers/Connacht)*
19. Cormac Izuchukwu (Ballynahinch/Ulster)(4)
20. Bryn Ward (Ballynahinch/Ulster)*
21. Nathan Doak (Banbridge/Ulster)(1)
22. Harry Byrne (Lansdowne/Leinster)(4)
23. Bundee Aki (Galwegians/Connacht)(70)
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