At least one person has been taken to University Hospital Kerry following a crash at the level crossing between Farranfore and Firies.
It's understood the injuries are not life threatening.
The road between Farranfore and Firies is closed as a result of the crash.
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Gardai and the emergency services are at the scene and diversions are in place.
Motorists are asked to avoid the area and delays on train routes are expected as a result.
According to Irish Rail, bus connections are in place between Killarney and Tralee until further notice due to the crash at Dromore level crossing.
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Irish Rail's Twitter account says emergency services are on site.
