There has been a 33% increase in meningitis cases in Kerry and Cork in a 12-month period.
The HSE has expressed concern after figures showed a rise in meningococcal disease from 12 cases in 2015 to 18 cases in 2016.
The Department of Public Health HSE South bulletin said there were two deaths from meningitis in 2016, both in elderly patients, one with a confirmed C strain.
The group was unavailable in the second case.
Six cases have been confirmed in Cork and Kerry in the first two months of this year.
The current menC vaccine schedule is at 6months old, with a booster at 13months, there is also an adolescent booster in 1st year in second level schools.
The HSE says uptake of the booster at 13months has shown a drop off compared to other vaccines for babies.
Although there has been an increase in cases figures remain lower than they were historically.