Ultane Dillane has been ruled out for the remainder of the season.
The Connacht second row has undergone successful surgery on a shoulder injury.
The province will also be without winger Matt Healy for up to six weeks after he damaged a hand in training.
There’s further injury woe for the Connacht, with Nepia Fox-Matamua sustaining an A-C-L injury in the recent win over Treviso and he’ll undergo surgery next week.
In better news for Pat Lam’s side, Kieran Marmion, Tiernan O’Halloran and Quinn Roux are all available for Saturday’s game with Glasgow having returned unscathed from Ireland duty.